LARS Score

Low Anterior Resection Syndrome Score

The LARS Score is a 5-item patient-reported outcome measure for bowel dysfunction following sphincter-preserving resection for rectal cancer. It classifies patients into No, Minor, or Major LARS based on symptoms over the past 4 weeks.

ColorectalQuality of LifePatient Reported
LARS Score (Past 4 Weeks)
These questions are about your current bowel function. Please answer based on your experience during the past 4 weeks.
5 Questions
LARS Score (0–42)

Interpretation

LARS ScoreCategoryClinical Significance
0–20No LARSBowel function does not significantly impact quality of life
21–29Minor LARSSome bowel dysfunction; may benefit from dietary advice and pelvic floor physiotherapy
30–42Major LARSSignificant impact on quality of life; specialist referral recommended

Background and Epidemiology

  • Prevalence: LARS affects 40–60% of patients after low anterior resection (LAR). Major LARS occurs in approximately 30–40%.
  • Time course: Symptoms are worst in the first 6–12 months after reversal of defunctioning stoma. Improvement occurs gradually over 12–24 months in most patients.
  • Risk factors for Major LARS: Low anastomosis (≤5 cm from anal verge), neoadjuvant radiotherapy, defunctioning stoma reversal, younger age (paradoxically).
  • Radiotherapy impact: Long-course neoadjuvant chemoradiation significantly increases Major LARS rates compared to surgery alone.

Clinical Application

  • Pre-operative counselling: Discuss LARS risk before sphincter-preserving surgery — this is essential for informed consent, particularly regarding stoma vs. anastomosis decisions.
  • Post-operative follow-up: Administer LARS Score at 3, 6, 12, and 24 months post-reversal to track recovery trajectory.
  • Major LARS management:
    • Dietary modification (low residue, regular meal timing)
    • Antidiarrhoeal agents (loperamide)
    • Pelvic floor physiotherapy and biofeedback
    • Transanal irrigation (TAI) — highly effective for clustering and urgency
    • Sacral nerve stimulation for severe refractory cases
  • Stoma consideration: In patients with predicted Major LARS and existing co-morbidities (especially pre-existing incontinence), permanent stoma may have a better quality of life outcome than anastomosis.

References

  1. Emmertsen KJ, Laurberg S. Low anterior resection syndrome score: development and validation of a symptom-based scoring system for bowel dysfunction after low anterior resection for rectal cancer. Ann Surg. 2012;255(5):922–928.
  2. Juul T, et al. International validation of the low anterior resection syndrome score. Ann Surg. 2014;259(4):728–734.
  3. Battersby NJ, et al. Prospective validation of a low anterior resection syndrome score. Ann Surg. 2016;263(6):1083–1091.

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