E-PASS Score

Estimation of Physiologic Ability and Surgical Stress
Predicts surgical morbidity and mortality in gastrointestinal surgery by combining a Pre-operative Risk Score (PRS) and a Surgical Stress Score (SSS). Validated by Haga et al. (2004) for open GI procedures.
Perioperative Risk GI Surgery Morbidity Prediction Surgical Scoring
E-PASS Calculator
Section A — Pre-operative Risk Score (PRS)
Section B — Surgical Stress Score (SSS)

E-PASS Formula

PRS = 0.001 × (−28.086 + 17.316×cHF + 17.316×cLD + 17.316×cDM + 17.316×cIMC + 17.316×ASA) SSS = 0.001 × (−0.342 + 0.357×BL_cat + 0.368×time_cat + 0.322×incision_cat) Where BL_cat: <100 mL/kg=0, 100–200 mL/kg=1, >200 mL/kg=2 Morbidity = e^(−1.402 + 2.073×PRS + 1.005×SSS) / [1 + e^(−1.402 + 2.073×PRS + 1.005×SSS)] Mortality = e^(−4.426 + 4.208×PRS + 1.905×SSS) / [1 + e^(−4.426 + 4.208×PRS + 1.905×SSS)]

PRS and SSS are intermediate scores with no direct clinical interpretation; only the derived morbidity and mortality probabilities are reported.

PRS Variables

Variable0 pts1 pt2 pts
Chronic heart failureNoneNYHA I–IINYHA III–IV
Chronic lung diseaseNoneMild (FEV1 70–80%)Severe (FEV1 <70% or home O2)
Diabetes mellitusNoneDiet / OHAInsulin-dependent
Performance statusNormalLimited demanding activityConfined >50% waking hours
ASAASA IASA IIASA III (2) / IV (3)

SSS Variables

Variable0 pts1 pt2 pts
Blood loss / weight<100 mL/kg100–200 mL/kg>200 mL/kg
Operative time<2.5 h2.5–5 h>5 h
Incision extentLaparoscopicOpen limitedOpen extended

Interpretation

Morbidity %RiskRecommendation
<20%LowStandard peri-operative care
20–40%ModerateHDU; senior anaesthetist; pre-operative optimisation
>40%HighICU; consider less invasive alternatives; detailed consent

Clinical Application

  • E-PASS was validated in 417 elective gastrointestinal surgery patients (Haga 2004, World J Surg)
  • PRS quantifies fixed patient risk; SSS quantifies modifiable surgical stress — surgeons can reduce SSS by choosing laparoscopic or shorter operations where oncologically equivalent
  • Useful for matching operative approach to patient risk: high PRS = minimise SSS by choosing minimal access surgery
  • PRS can be calculated pre-operatively; SSS is retrospectively applied after the operation for quality reporting purposes
  • E-PASS is widely used in Japanese surgical quality programmes and GI surgery audits

References

  1. Haga Y, et al. Estimation of physiologic ability and surgical stress (E-PASS) as a new prediction scoring system for postoperative morbidity and mortality following elective gastrointestinal surgery. Surg Today. 2004;34(3):208–214.
  2. Haga Y, et al. Assessment of the estimation of physiologic ability and surgical stress score as a predictor of postoperative surgical outcome. J Gastrointest Surg. 2012;16(3):486–492.

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